Therapeutic Targets: PI3K
The phosphoinositide 3-kinases (PI3Ks) are a family of enzymes involved in key immune cell functions, including cell proliferation and survival, cell differentiation and cellular trafficking. PI3K delta and gamma, two isoforms of PI3K, play key roles in inflammatory and autoimmune diseases. Additionally, in certain hematologic malignancies, PI3K delta and gamma contribute to the survival and proliferation of cancer cells. Therefore, inhibition of PI3K delta and gamma may have therapeutic potential across a broad range of inflammatory diseases and hematologic malignancies.
We are developing IPI-145, a potent oral inhibitor of PI3K delta and PI3K gamma. IPI-145 is currently being evaluated in two Phase 1 clinical trials. The first is a is a double-blind, randomized, placebo-controlled study designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple escalating doses of IPI-145 in healthy adult subjects. The second trial is an open-label, dose-escalation study designed to evaluate the safety, pharmacokinetics and clinical activity of IPI-145 in patients with advanced hematologic malignancies.
We are collaborating with Intellikine, Inc. to identify additional selective PI3K inhibitors for development.